Pancreatic ductal adenocarcinoma (PDAC) is an invasive pancreatic epithelial neoplasm with glandular (ductal) differentiation, usually demonstrating luminal or intracellular mucin and without a substantial …

Herein, we describe the detailed protocol for IHC analyses of pancreatic intraepithelial neoplasia in tissues and fine needle aspirates from both human and mouse samples.

May 3, 2023 · Immunohistochemistry serves as an ancillary diagnostic tool for a wide variety of neoplastic and nonneoplastic disorders, including infections, workup of inflammatory conditions, and …

Dec 20, 2021 · This review will analyze and synthesize published articles to provide an insight into potential IHC biomarkers for pancreatic cancer diagnosis.

Mar 5, 2025 · Results: Three tumor immunotypes were identified: subtype A (hot immunotype), subtype B (intermediate immunotype), and subtype C (cold immunotype). Patients with immunotype C exhibit …

Mar 4, 2025 · In this study, we evaluated the prognostic utility of GATA6 immunohistochemistry (IHC), measured with digital assistance, in the ESPAC-4 trial of adjuvant chemotherapy for pancreatic …

Jul 6, 2024 · We aimed to evaluate the utility of immunohistochemistry (IHC) expression subtypes generated by unsupervised hierarchical clustering based on staining scores of four markers (CK5/6, …

Sep 1, 2019 · The goal of this study was to determine whether the selected biomarkers could successfully be combined into a panel to identify pancreatic adenocarcinoma at a high sensitivity and …

This scoping review analyzes the ethical landscape of using immunohistochemistry (IHC) for molecular subtyping in PDAC, focusing on its utility, accessibility, and potential impact on patient care.

Dec 6, 2023 · Biallelic loss of CDKN2A occurs in up to 46% of PDACs, and methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) has been identified as a reliable surrogate …