A virus relies on the host's translation machinery to replicate itself and become infectious. Translation efficiency ...

In translation, aa-tRNA, EF-Tu and GTP form a ternary complex that binds to the ribosome, allowing codon-anticodon pairing in the 30S ribosomal subunit. Cognate codon recognition triggers fast GTP ...

Alltrna is advancing a new class of genetic medicines based on the power of tRNA biology to universally treat Stop Codon Disease, which encompasses thousands of genetic diseases caused by a premature ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

The various identities of cells, whether they are in the brain, heart, kidney, or any other tissue, are defined by the genes they expressed. In basic terms, the genes that are active in a cell are ...

Gene editing can repair mutations that prematurely halt protein synthesis, resulting in incomplete peptides that cause various diseases. However, other approaches achieve the same effect without ...

Rare diseases, defined by FDA as “a disease or condition that affects less than 200,000 people in the United States” (1), may ...

Peking University, June 27, 2025: To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University ...

During protein synthesis, the genetic information stored in DNA is first transcribed into mRNA. The mRNA then travels to the ribosome, where translation occurs. Here's how anticodons facilitate the ...

BOSTON--(BUSINESS WIRE)--hC Bioscience, a biopharmaceutical company developing a fundamentally novel approach to treating genetic diseases through tRNA-based protein editing, today presented ...

A virus relies on the host's translation machinery to replicate itself and become infectious. Translation efficiency ...