Expression of rRNA affects cell growth and proliferation, but mechanisms that modulate rRNA levels are poorly understood. We conducted a genetic screen for factors that negatively regulate generation ...
In eukaryotes, formation of short duplexes between the U3 small nucleolar RNA (snoRNA) and the precursor rRNA (pre-rRNA) at multiple sites is a prerequisite for three endonucleolytic cleavages that ...
In mammalian cells, the nucleolus is the central site for ribosome biogenesis. It is composed of distinct subcompartments: the fibrillar center (FC), the dense fibrillar component (DFC), the periphery ...
This is a preview. Log in through your library . Abstract The four nucleolar proteins NOP1, SSB1, GAR1, and NSR1 of Saccharomyces cerevisiae share a repetitive domain composed of repeat units rich in ...
(a) FISH of pre-18S and pre-28S rRNA in mouse early embryos. Yellow triangles indicate pre-rRNA signal within the NPB or nucleolus. Scale bar, 20 μm. (b) Fluorescence of CYTO signal in mouse early ...
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