Endoplasmic reticulum–associated degradation (ERAD) is a cellular protein quality-control process that disposes of proteasomal substrates from the early secretory pathway. Recent work shows that the ...
Three families of polytopic proteases with membrane-embedded active sites have been discovered: site 2 proteases (S2Ps) are metalloproteases, presenilin-type aspartyl proteases are represented widely ...
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