Substituting amines with phosphonium-based cations could greatly improve the performance of mRNA-loaded polymeric micelles, report scientists. By adopting this innovative strategy, they managed to ...

(a) Anionic Lipo-ORG enabled effective access to lymphatics and high accumulation in lymph nodes. Effective cellular entry and endosome escape of mRNA and cGAMP was achieved in DCs and potentiated ...

This presentation explores cutting-edge artificial intelligence (AI) approaches for the rational design of nucleic acid therapeutics, including linear mRNA, circular RNA (circRNA), and small ...

RNA interference (RNAi) is a method for targeted gene silencing. It is a highly valuable and widely used technique for the study of gene function and for drug discovery research. During RNAi, ...

An mRNA-based flu vaccine designed to offer long-lasting protection against a broad range of influenza viruses is now in a phase I clinical trial, the National Institutes of Health announced this week ...

Among the vastly different ways of tackling a disease, controlling the genetic expression of cells is undoubtedly one of the most powerful. Over the past few decades, scientists have come up with ...

Since mRNA itself is quite unstable and easily destroyed by enzymes in the body, mRNA-based therapies rely on drug delivery techniques; the core idea is to encapsulate and protect mRNA molecules ...