Cadherin-based adherens junctions (AJs) mediate cell adhesion and regulate cell shape change. The nectin-afadin complex also localizes to AJs and links to the cytoskeleton. Mammalian afadin has been ...

Cell–cell adhesion is crucial during epithelial development and morphogenesis, with adherens junctions being the main intercellular structures. At each adherens junction, the calcium-dependent ...

Scientists at the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) have discovered the molecular mechanisms responsible for the formation of the adherens junction at the ...

Epithelial cells are held together and connected by several different types of structures that form cell-cell contacts. One of these structures, found near the top surface of the cell, is the adherens ...

Epithelial cells are held together and connected by several different types of structures that form cell-cell contacts. One of these structures, found near the top surface of the cell, is the adherens ...

Necrotizing enterocolitis (NEC) is a devastating disease of premature babies. Previously, we have shown that EGF reduces NEC and that overproduction of hepatic TNF-α is associated with intestinal ...